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5-[(3-Nitropyrid-2-yl)amino]indoles: Novel Serotonin Agonists with Selectivity for the 5-HT1D Receptor. Variation of the C3 Substituent on the Indole Template Leads to Increased 5-HT1D Receptor Selectivity

โœ Scribed by Macor, John E.; Blank, David H.; Fox, Carol B.; Lebel, Lorraine A.; Newman, Michael E.; Post, Ronald J.; Ryan, Kevin; Schmidt, Anne W.; Schulz, David W.; Koe, B. Kenneth


Book ID
126057207
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
498 KB
Volume
37
Category
Article
ISSN
0022-2623

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## Abstract The synthesis of [^3^H]CPโ€96,501 [5โ€(2,3โ€ditritiopropoxy)โ€3โ€(1,2,5,6โ€tetrahydropyridโ€4โ€yl)indole], a selective radioligand for the serotonin (5โ€HT~1B~) receptor and analog of RUโ€24,969, is described. 5โ€Hydroxyindole is converted in two steps to 5โ€(2โ€propenyloxy)โ€3โ€(Nโ€__t__โ€butoxycarbony