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(.+-.)-3-Amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole: a conformationally restricted analog of 5-carboxamidotryptamine with selectivity for the serotonin 5-HT1D receptor

✍ Scribed by King, Frank D.; Brown, Anthony M.; Gaster, Laramie M.; Kaumann, Alberto J.; Medhurst, Andrew D.; Parker, Stephen G.; Parsons, Andrew A.; Patch, Tracey L.; Raval, Pravin


Book ID
120632313
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
208 KB
Volume
36
Category
Article
ISSN
0022-2623

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✍ John E. Macor; Carol A. Burkhart; Lorraine A. Lebel; B. Kenneth Koe; Phillip M. 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 431 KB

## Abstract The synthesis of [^3^H]CP‐96,501 [5‐(2,3‐ditritiopropoxy)‐3‐(1,2,5,6‐tetrahydropyrid‐4‐yl)indole], a selective radioligand for the serotonin (5‐HT~1B~) receptor and analog of RU‐24,969, is described. 5‐Hydroxyindole is converted in two steps to 5‐(2‐propenyloxy)‐3‐(N‐__t__‐butoxycarbony