Synthesis and Properties of the Antileukemic Agent 5 ( or 4)-[ 3,3-Bis( 2-~hloroethyl)-~-triazeno]irnidazole-4( or 5)-carboxamide By Y. FULMER SHEALY, CHARLES A. KRAUTH\*, LEE B. HOLUM, and WILLIAM E. FITZGIBBON The antileukemic agent 5 (or 4 ) -I 3,3 -bis (2-chloroeth yl) -1 -triazeno]imidazole-4(o
5-[3-(2-chloroethyl)-1-triazenyl]imidazole-4-carboxamide and a possible mechanism of action of 5-[3,3-bis(2-chloroethyl)-1-triazenyl]imidazole-4-carboxamide
β Scribed by Y. Fulmer Shealy; C. Allen O'Dell; Charles A. Krauth
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 431 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3549
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π SIMILAR VOLUMES
Reaction of dimethylamine 14C with a four-fold molar excess of 5-diazoimidazole-4-carboxamide in methanol followed by column chromatography of the product on basic a1 umina afforded 5-3,3-dimethyl-4C-l-triazeno)imi datole-4-carboxamide in 70-75% yield and greater than 99.9% radiochemical purity. The
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