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An efficient and convenient synthesis of 5-(3,3-dimethyl-14C-1-triazeno)-imidazole-4-carboxamide

✍ Scribed by D. Farquhar; J. A. Benvenuto; Ti Li Loo

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
279 KB
Volume
16
Category
Article
ISSN
0022-2135

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✦ Synopsis

Reaction of dimethylamine 14C with a four-fold molar excess of 5-diazoimidazole-4-carboxamide in methanol followed by column chromatography of the product on basic a1 umina afforded 5-3,3-dimethyl-4C-l-triazeno)imi datole-4-carboxamide in 70-75% yield and greater than 99.9% radiochemical purity. The preparation is suitable for chemical and biological mechanistic studies.

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