✍ Scribed by Salvador Vega; María Esther Arranz
No coin nor oath required. For personal study only.
This paper deals with the synthesis of a number of new 4__H__‐thieno[3,4‐e] and 4__H__‐pyrazolo[4,3‐e]‐1,2,4‐thiadiazine 1,1‐dioxide derivatives 1, the study of their chemical behavior in some alkylation reactions and the evaluation of their vasorelaxant effects on spontaneous motility and on tension responses to increased extracellular KCl concentrations in isolated rat portal vein.
📜 SIMILAR VOLUMES
## Abstract Attempted hydrolysis of the ester of 3‐methoxycarbonyl‐1__H__‐thieno[2,3‐__e__][1,3,4]thiadiazine 4,4‐dioxide (**I**) under acidic conditions gave the ring‐contracted thieno[2,3‐__d__][1,2,3]thiadiazole (**V**) instead of the expected carboxylic acid. In addition to a discussion of the
## Abstract magnified image Two series of 4__H__‐pyrido[4,3‐__e__]‐1,2,4‐thiadiazine derivatives **3**, **4**, **5** and **7**, **8**, **9**, **10**, **11**, **12** were synthesized by the reactions of 3‐methylthiopyrido[4,3‐__e__]‐1,4,2‐dithiazine 1,1‐dioxide **1** with 2‐or 6‐hydrazinoazines and