49 P - Frequent replication errors at microsatellite loci on chromosomes 2p and 3p in non-small cell lung cancer
✍ Scribed by A. Pifarré; M. Monzó; J.M. de Anta; I. Moreno; A. Aldea; M. Krüger; A. Ariza
- Book ID
- 116168328
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 189 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0959-8049
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Deletions involving the chromosome 9p21 region have been reported as frequent events in non-small cell lung cancer (NSCLC). To investigate potential tumor-suppressor gene (TSG) loci within the 9p21 region, which also harbors the candidate TSG locus CDKN2a, we studied 32 cases of primary NSCLC for lo
We examined 82 cases of primary non-small cell lung cancer (NSCLC) for loss of heterozygosity (LOH) at the chromosome 9p21-24 region using 16 microsatellite markers. A total of 52 tumors (63%) displayed LOH, and 25 of these cases displayed LOH for all markers. Two cases had small hemizygous losses c