482. Modified steroid hormones. Part XV. A new route to 17α-alkynyl-17β-hydroxy-steroids
✍ Scribed by Ellis, B. ;Petrow, V. ;Stansfield, M. ;Weston, G.
- Book ID
- 120328251
- Publisher
- The Royal Society of Chemistry
- Year
- 1960
- Weight
- 333 KB
- Volume
- 0
- Category
- Article
- ISSN
- 0368-1769
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We have discovered that chlorine in 3~-acetoxy-17-chloro-16-formylandrosta-5,16-diene (1) can be smoothly displaced by nitrogen heterocyclic nucleophiles (her) to give heretofore unknown 17-substituted-A t6 steroids in high yields (73-92%). This enabled us to synthesize novel 3~-hydroxy-17-(1H-1,2,4
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