476 Germline MYH mutations and risk of colorectal cancer
β Scribed by M. Croitoru; S. Cleary; N. Di Nicola; M. Manno; M. Aaronson; M. Redston; M. Cotterchio; J. Knight; R. Gryfe; S. Gallinger
- Book ID
- 118621658
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 145 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1359-6349
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π SIMILAR VOLUMES
Germinal mutations in the base excision repair (BER) gene MUTYH (MYH) have recently been described in association with predisposition to multiple colorectal adenomas and cancer. In contrast to the classic dominant condition of familial adenomatous polyposis (FAP) due to germinal mutations in the APC
## Dear Sir In a recent study published in the International Journal of Cancer, Fleischmann et al. 1 described the results of screening for germline mutations in the human homolog of the E. coli mutY gene (MYH) in a series of 358 individuals affected with early-onset colorectal cancer (CRC), arbit