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4711880 Crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate


Book ID
122759954
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
56 KB
Volume
6
Category
Article
ISSN
0734-9750

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The synthesis of disodium-3-amino-1-hydr
✍ Ernest Magnien; Mujahid Shaikh; John T. Suh; Howard Jones πŸ“‚ Article πŸ“… 1982 πŸ› John Wiley and Sons 🌐 French βš– 169 KB

## Abstract Disodium‐3‐amino‐1‐hydroxy‐1, 1‐diphosphonate‐1‐^14^C (APD 2Na), a powerful calcium binding agent and potential drug for the treatment of Paget's Disease was synthesized. The reaction was carried out by reacting β‐alanine (1‐^14^C) with phosphorus acid and phosphorus trichloride in chlo