๐”– Bobbio Scriptorium
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421 Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor-3

โœ Scribed by Tsuyoshi Yamashiro; Masayuki Kurosaki; Naoya Sakamoto; Nobuyuki Enomoto; Nobuhiko Kanazawa; Yoko Tanabe; Shinya Maekawa; Mina Nakagawa; Cheng-Hsin Chen; Mamoru Watanabe


Book ID
119530329
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
107 KB
Volume
38
Category
Article
ISSN
0270-9139

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A new survival trick of hepatitis C viru
โœ Markus H. Heim ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 105 KB

Persistent infections with hepatitis C virus (HCV) are likely to depend on viral inhibition of host defenses. We show that the HCV NS3/4A serine protease blocks the phosphorylation and effector action of interferon regulatory factor-3 (IRF-3), a key cellular antiviral signaling molecule. Disruption