Persistent infections with hepatitis C virus (HCV) are likely to depend on viral inhibition of host defenses. We show that the HCV NS3/4A serine protease blocks the phosphorylation and effector action of interferon regulatory factor-3 (IRF-3), a key cellular antiviral signaling molecule. Disruption
Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3
โ Scribed by Tsuyoshi Yamashiro; Naoya Sakamoto; Masayuki Kurosaki; Nobuhiko Kanazawa; Yoko Tanabe; Mina Nakagawa; Cheng-Hsin Chen; Yasuhiro Itsui; Tomoyuki Koyama; Yoshie Takeda; Shinya Maekawa; Nobuyuki Enomoto; Hiroshi Sakugawa; Mamoru Watanabe
- Publisher
- Springer Japan
- Year
- 2006
- Tongue
- English
- Weight
- 247 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0944-1174
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