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4′-Substituted analogues of idoxifene: Antiestrogens and calmodulin antagonists

✍ Scribed by Ian R Hardcastle; Martin G Rowlands; John Houghton; Michael Jarman

Book ID: 103982894
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 202 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00117-c

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✦ Synopsis

4'-substituted analogues of the antiestrogen idoxifene have been prepared. All the compounds were assayed for antagonism of calmodulin dependent c-AMP phosphodiesterase and for binding to rat uterine estrogen receptor. The 4'-amino compound was the most potent antiestrogen (RBA = 47) whilst retaining a similar calmodulin antagonism to idoxifene.

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