✦ LIBER ✦
Synthesis of 4-stannylated tamoxifen analogues; useful precursors to radiolabelled idoxifene and aziridinyl 4-iodotamoxifen
✍ Scribed by Raymond McCague; Gerard A. Potter
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 321 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The 4‐stannylated tamoxifen analogues (E)‐1‐[4‐[2‐(N‐pyrrolidino)ethoxy]phenyl]‐1‐[4‐(tributylstannyl)phenyl]‐2‐phenyl‐1‐butene and (E)1‐[4‐[2‐(aziridin‐1‐yl)ethoxy]phenyI]‐1‐[4‐(tributylstannyl)phenyl]‐2‐phenyl‐1‐butene have been synthesised as precursors to radiolabelled idoxifene, an important new drug for the treatment of breast cancer, and to aziridinyl 4‐iodotamoxifen, a potentially useful biological research tool for studying the action of tamoxifen, respectively.