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4-quinolones inhibit biotransformation of caffeine

✍ Scribed by S. Harder; A. H. Staib; C. Beer; A. Papenburg; W. Stille; P. M. Shah

Publisher
Springer
Year
1988
Tongue
English
Weight
687 KB
Volume
35
Category
Article
ISSN
0031-6970

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## Objectives: The biotransformation of caffeine has been studied in vitro using human cytochrome p-450 isoenzymes (cyps) expressed in human b-lymphoblastoid cell lines, namely cyp1a1, 1a2, 2a6, 2b6, 2d6-val, 2e1 and 3a4, and microsomal epoxide hydroxylase (eh). in addition, cyp2d6-met was also stu