✦ LIBER ✦

4-pregnene-3-one-20β-carboxaldehyde: A potent inhibitor of 17α-hydroxylase/C17,20-lyase and of 5α-reductase

✍ Scribed by Li, Jisong; Li, Yan; Son, Chong; Banks, Philippa; Brodie, Angela

Book ID: 121910840
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 626 KB
Volume: 42
Category: Article
ISSN: 0960-0760
DOI: 10.1016/0960-0760(92)90134-5

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

20-Amino and 20,21-aziridinyl pregnene s

20-Amino and 20,21-aziridinyl pregnene steroids: Development of potent inhibitors of 17α-hydroxylase/C17,20-lyase (P450 17)

✍ Vincent C.O. Njar; Markus Hector; Rolf W. Hartmann 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 476 KB

In the search for potent inhibitors of P450 17, the key enzyme of androgen biosynthesis, the 20,21-aziridinyl- and 20-aminopregnene steroids 1-11 were synthesized and tested toward rat testicular P450 17. Only the aziridinyl-substituted pregnenolones (1 and 2) and progesterones (3 and 4), respective

Synthesis and in vitro activity of some

Synthesis and in vitro activity of some epimeric 20α-hydroxy, 20-oxime and aziridine pregnene derivatives as inhibitors of human 17α-hydroxylase/c17,20-lyase and 5α-reductase

✍ Yang-zhi Ling; Ji-song Li; Katsuya Kato; Yang Liu; Xin Wang; Gregory T Klus; Kir 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 210 KB

Effect of inhibitors on testicular micro

Effect of inhibitors on testicular microsomal steroid 17α-hydroxylase and 17α-hydroxypregnene C17–C20 lyase

✍ Mikio Shikita; Tomoko Ogiso; Bun-Ichi Tamaoki 📂 Article 📅 1965 🏛 Elsevier Science ⚖ 392 KB

The synthesis of 3β, 11β-dihydroxy-5-and

The synthesis of 3β, 11β-dihydroxy-5-androsten-17-one, 5-pregnene-3β, 11β, 17α, 20α-tetrol and 5-pregnene-3β, 11β, 17α, 20β-tetrol tritiated at C-1

✍ G. Halperin; J. Weidenfeld 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 169 KB 👁 1 views

3p-hydroxy-ateroidm, i a deacribed: 3p, 1 1 p-di hydroxy-5-androaten-17-one, 5-pregnene-3ps 1lP,17ab2Oa-tetrol and 5-preqnene-3p,1lps 17a , top-tetrol.

17β-(Cyclopropylamino)-androst-5-en-3β-o

17β-(Cyclopropylamino)-androst-5-en-3β-ol, a selective mechanism-based inhibitor of cytochrome P45017α (steroid 17α-hydroxylase/C17–20 lyase)

✍ Michael R. Angelastro; Marie E. Laughlin; Gerald L. Schatzman; Philippe Bey; Tho 📂 Article 📅 1989 🏛 Elsevier Science 🌐 English ⚖ 425 KB

4,5-Dihydro-3-(2-pyrazinyl)naphtho[1,2-c

4,5-Dihydro-3-(2-pyrazinyl)naphtho[1,2-c]pyrazole: A Potent and Selective Inhibitor of Steroid-17α-Hydroxylase-C17,20-Lyase (P450 17)

✍ Rolf W. Hartmann; Gerald A. Wächter; Tom Sergejew; Rieka Würtz; Jörg Düerkop 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 295 KB 👁 2 views