4-Oxo-1H-and-2H-[1]benzopyrano[4,3-c]pyrazoles. Preparation from 4-hydroxycoumarin or 3-chromonecarboxylic acid derivatives.
✍ Scribed by Bernard Chantegrel; Abdel-Ilah Nodi; Suzanne Gelin
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 234 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Summatry :
The convemion 06 3-a_cy~-4-hy~oxycoumanin~ Xo eLthe,t 4-oxo-l-phenyt-IH-[J]bwzo-
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Various trisubstituted [1]benzopyrano[4,3-b]pyrrol-4(1H)-one derivatives have been synthesized from 4-hydroxycoumarin with a 30-40% yield over six steps. The key step of the synthesis is a base-promoted intramolecular cyclization of enamines 5, followed by dehydration to generate the fused pyrrole r
## Abstract A one‐step ‘ring switching’ transformation of (__S__)‐3‐[(dimethylamino)methylidene]‐5‐(methoxycarbonyl)tetrahydrofuran‐2‐one (**4**) with 2‐pyridineacetic acid derivatives (**5–7**) and 2‐aminopyridines (**8, 9**) afforded the corresponding 3‐(4‐oxo‐4__H__‐quinolizinyl‐3)‐ **(15–17)**
Reaction of 4H-3.1-benzothiazine-4-lhiones 1 with S-methylisothiosemicarbazide hydroiodide yields bamino-1.3.4-thiadiazoles 2 insteud of the espected 1.2,4-triazolo[3,2-c]quinazolines. Structures of compounds 2 have been established by mcans of '>C-N M R analysis and X-ray crystallography. 3-Arnino-
A series of novel 7- (3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3carboxylic acid derivatives was designed, synthesized and characterized by 1 H-NMR, MS and HRMS. These fluoroquinolones were evaluated for their in-vitro antibacterial activity against representat