## Abstract Intramolecular condensation of the __N__‐(4‐amino‐5‐nitrosopyrimidin‐4‐yl)‐2‐chloroacetamide **2** led to the pteridinone __N(5)__‐oxide **4**, while treatment of **2** with Me~3~P yielded the 8‐(chloromethyl)purine **3**. A high‐yielding [3+2] dipolar cycloaddition of the __N(5)__‐oxid
4-Methyl-5-hydroxypyrimidine and its N-oxides: Synthesis and investigation of the reactivities in electrophilic substitution
✍ Scribed by S. B. Gashev; L. V. Gol'tsova; L. D. Smirnov; V. P. Lezina
- Publisher
- Springer US
- Year
- 1989
- Tongue
- English
- Weight
- 584 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0009-3122
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📜 SIMILAR VOLUMES
Oxidative Alkylation of Azoles. Part 5. Synthesis of 4-Nitro-N-chloroimidazole and Its Reaction with Methyl Iodide. -Chlorination of 4-nitroimidazole (I) in alkaline solution affords the 4-nitro-Nchloroimidazole (II) in almost quantitative yield. Chloroimidazole (II) undergoes oxidative alkylation w
In the oxidation 06 the tit\_& compoun&, 5-e~hyL-4a-hydtopehoxy-3-me,thyL-Lumi&win (4a-F1Et-OUH), wan dound to be an eleca7tophLL.k oxidant dim&m to m-ckeohopehaxybenzoic acid.
## Abstract The compounds 5‐ethoxycarbonyl‐1,6‐dimethyl‐4‐(3‐nitrophenyl)‐3,4‐dihydropyrimidin‐2(l__H__)‐one (5) and 5‐ethoxycarbonyl‐1‐phenyl‐6‐methyl‐4‐(3‐nitrophenyl)‐3,4‐dihydropyrimidin‐2(l__H__)‐one (1) were prepared by the Biginelli condensation method and they converted to eight N‐3 substit