4-Hydroxynonenal–protein adducts: A reliable biomarker of lipid oxidation in liver diseases
✍ Scribed by Giuseppe Poli; Fiorella Biasi; Gabriella Leonarduzzi
- Book ID
- 116727957
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 102 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0098-2997
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The precise role of lipid peroxidation in the pathogenesis of alcoholic liver disease is still being debated. To explore the issue, this study was undertaken to investigate the status of lipid peroxidation, antioxidants and prooxidants at two discrete stages of experimental alcoholic liver disease.
modification by acetaldehyde correlates well with the severity Liver proteins form adducts with acetaldehyde and are of liver injury in ethanol-fed rats, whereas modification by modified by products of lipid peroxidation in alcohol-fed anithe lipid peroxidation product 4-HNE shows no correlation mal