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Revealing 4-hydroxynonenal-histidine adducts as qualitative and quantitative biomarker of oxidative stress, lipid peroxidation and oxidative homeostasis

✍ Scribed by Zarkovic, N.; Zarkovic, K.; Milkovic, L.; Andrisic, L; Borovic, S.; Waeg, G.; Weber, D.; Bennett, Stuart J.; Griffith, Helen R.; Gune, T.


Book ID
122992610
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
81 KB
Volume
65
Category
Article
ISSN
0891-5849

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## Abstract Hemoglobin (Hb) adducts have long been used as dosimeters of exposure to xenobiotics and endogenously formed reactive metabolites. In this study, hemoglobin chains were separated from each other and their prosthetic heme groups and reacted with 4‐oxo‐2‐nonenal, a major breakdown product