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4-Hydroxynonenal induces vascular smooth muscle cell apoptosis through mitochondrial generation of reactive oxygen species

✍ Scribed by Ji Young Lee; Geun Young Jung; Hye Jin Heo; Mi Ran Yun; Ji Young Park; Sun Sik Bae; Ki Whan Hong; Won Suk Lee; Chi Dae Kim


Book ID
119379009
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
485 KB
Volume
166
Category
Article
ISSN
0378-4274

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Peroxyacetyl nitrate (PAN), an ubiquitous air pollutant, induced apoptosis in human leukemia HL-60, human chronic myelogenous leukemia K-562, and mouse monocyte-macrophage RAW 264.7 cell lines. In the HL 60 cells, characteristic apoptosis morphology could be observed 4 h after the cells were treated