Increased levels of reactive oxygen species occur in neurodegenerative disorders and may promote neuron death. The lipid peroxidation product 4-hydroxynonenal (HNE) is increased in neurons following oxidative stress and promotes neuron death in vitro and in vivo. The present study examined the possi
✦ LIBER ✦
4-Hydroxynonenal in the Pathomechanisms of Oxidative Stress
✍ Scribed by Giuseppe Poli; Jörg R. Schaur
- Book ID
- 111743390
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 210 KB
- Volume
- 50
- Category
- Article
- ISSN
- 1521-6543
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4-Hydroxynonenal (HNE) is by far the most investigated aldehydic end-product of oxidative breakdown of membrane n-6 polyunsaturated fatty acids. Its potential involvement in the pathogenesis of atherosclerosis has been corroborated by its consistent detection in both oxidized LDL and fibrotic plaque