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4-Arylphthalazin-1(2H)-one derivatives as potent antagonists of the melanin concentrating hormone receptor 1 (MCH-R1)

✍ Scribed by Chae Jo Lim; Soo Hee Kim; Byung Ho Lee; Kwang-Seok Oh; Kyu Yang Yi


Book ID
119203729
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
494 KB
Volume
22
Category
Article
ISSN
0960-894X

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Melanin-concentrating hormone (MCH) is a 19-amino-acid cyclic peptide which was originally found to lighten skin color in fish that is highly conserved among many species. MCH interacts with two G-protein-coupled receptors, MCH1R and MCH2R, but only MCH1R is expressed in rodents. MCH is mainly synth