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4-anilidopiperidine analgesics I: Synthesis and analgesic activity of certain ring-methylated 1-substituted 4-propananilidopiperidines

โœ Scribed by Thomas N. Riley; Danny B. Hale; Marvin C. Wilson

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
476 KB
Volume
62
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

acid, base, and enzymatic degradations of I which involve the loss of the 3-position substituent.

When taking into consideration the work of Jones et al. (l), it is believed that the polarographic method should be generally applicable to all cephalosporins containing a leaving group at the 3position. Those free leaving groups containing a thiol functionality should also be amenable to polarographic determination Di a oxidative mercurous salt formation.

REFERENCES

(1) I. F. Jones, J. E.

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โœ Vittal S. Pai; Anilkumar P. Parulkar; Arnold R. Martin; A. I. White ๐Ÿ“‚ Article ๐Ÿ“… 1971 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 696 KB

The synthesis of five 2-methyl-and 2-benzyl-4,4-dimethyl-2-aminotetralins is described and their analgesic potencies are reported. The introduction of methyl or benzyl substituents in the 2-position does not appear to significantly affect analgesic potency in the 2-aminotetralin series. Keyphrases 2