4-Amino-6-benzylamino-1,2-dihydro-2-phenyl-1,2,4-triazolo[4,3-α]-quinoxalin-1-one: A New A2A Adenosine Receptor Antagonist with High Selectivity versus A1 Receptors
✍ Scribed by Vittoria Colotta; Daniela Catarzi; Flavia Varano; Lucia Cecchi; Guido Filacchioni; Claudia Martini; Letizia Trincavelli; Antonio Lucacchini
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 64 KB
- Volume
- 332
- Category
- Article
- ISSN
- 0365-6233
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Some 1,2,4‐triazolo[4,3‐__a__]quinoxalines 1–10, and 1,2,4‐triazino[4,3‐__a__]quinoxalines 11–12 were prepared and biologically evaluated for their binding at the benzodiazepine receptor (BZR) in rat cortical membranes. The BZR affinity of 1–10 demonstrates that the presence of a proton
The excessive release of glutamate, a potent excitatory neurotransmitter, is thought to play an important role in a variety of acute and chronic neurological disorders. Consequently, excitatory amino acid antagonists may have an important therapeutic potential in the treatment of these diseases. Glu