4-Acetamidocyclohexanone Semicarbazone Dihydrate
✍ Scribed by Zhou, K. J. ;Di Maio, G. ;Portalone, G. ;Li, S.
- Book ID
- 114511964
- Publisher
- International Union of Crystallography
- Year
- 1995
- Tongue
- English
- Weight
- 330 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0108-2701
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📜 SIMILAR VOLUMES
Synthesis of the Morphane Skeleton from 4‐Acetamidocyclohexanone 4‐Acetamidocyclohexanone (1) was substituted via the enamine 2 to yield the estermaids 3a and 4. By means of sodium hydride the __cis__ isomer of the acetal 3b could be cyclized to give the 2‐azabicyclo[3.3.1]nonane (morphane) 5.
In the title compound, C 10 H 13 N 3 S, the isopropylidineamine and phenyl groups are trans and cis, respectively, with respect to the thione group across their C-N bonds. The molecule is stablized by intra-and intermolecular hydrogen bonds to form dimers parallel to (010).
A series of aryloxyaryl semicarbazones had been shown previously to possess significant anticonvulsant activity in the maximal electroshock screen in both rats and mice as well as in the subcutaneous pentylenetetrazol test in mice. One member of this series, namely 4-(4′-fluorophenoxy)benzaldehyde s