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4-1BB Costimulation Promotes Human T Cell Adhesion to Fibronectin

✍ Scribed by Young-June Kim; Patricia L. Mantel; Carl H. June; Seung H. Kim; Byoung S. Kwon


Book ID
112240061
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
635 KB
Volume
192
Category
Article
ISSN
0008-8749

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## Abstract The T cell surface protein CD28 provides a critical costimulatory signal for T cell activation. With age, humans accumulate increasing numbers of CD28^–^ T cells, and this loss of CD28 expression is exacerbated certain disease states, such as HIV infection, autoimmune conditions or canc