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4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators

✍ Scribed by Hermogenes N. Jimenez; Kevin G. Liu; Sang-Phyo Hong; Michael S. Reitman; Michelle A. Uberti; Maria D. Bacolod; Manuel Cajina; Megan Nattini; Michael Sabio; Darío Doller


Book ID
113496788
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
605 KB
Volume
22
Category
Article
ISSN
0960-894X

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Based on SAR in the alkyne class of mGlu5 receptor negative allosteric modulators and a set of amidebased positive allosteric modulators, optimized substitution of the aryl 'b' ring was used to create substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides. Results from an mGlu5 receptor functional a