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(3S,7R,11E)-3,4,5,6,7,8,9,10-Octahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecen-1-one methanol solvate
β Scribed by Watson, W. H. ;Zabel, V. ;Mirocha, C. J. ;Pathre, S. V.
- Book ID
- 114528364
- Publisher
- International Union of Crystallography
- Year
- 1982
- Weight
- 432 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0567-7408
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The title compound, C 21 H 20 ClN 3 O 2 , was synthesized by the reaction of 4-chlorobenzaldehyde and 3-(5,5-dimethyl-3-oxocyclohex-1-enylamino)propanoic acid with malononitrile in ethylene glycol under microwave irradiation. The dihydropyridine ring has a boat conformation. The pyrimidine ring adop
Hydrogenation of the ketone group in di-0-benzylderivative (8) of the known macrocyclic lactone zeralenone (7) using a novel chiral borane complex 3.BH3, prepared in situ, proceeded at lower temperatures with moderate diastereoselectivity ( -40%, d.e. at -60"). Unsaturated diastereomers 9 and 10 wer
The title compound, C~22~H~29~NO~4~S, crystallizes with three independent molecules, __A__, __B__ and __C__, in the asymmetric unit. Each of the three independent molecules adopts a folded conformation, with the phenylsulfonyl group lying over the pyranocyclohexanone ring system, and with the pyrrol