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[3H]A-81988, a potent, selective, competitive antagonist radioligand for angiotensin AT1 receptors

✍ Scribed by Arthur A. Hancock; Bruce W. Surber; Gary Rotert; Samuel Thomas; Andrew S. Tasker; Bryan K. Sorensen; Alex D. Vodenlich; Terry J. Opgenorth; Daniel J. Kerkman; John F. DeBernardis

Book ID: 113398811
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 517 KB
Volume: 267
Category: Article
ISSN: 0922-4106
DOI: 10.1016/0922-4106(94)90223-2

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Recently, we reported the bioisosteric substitution of a guanidine by an acylguanidine entity in argininamide-type neuropeptide Y (NPY) Y 1 receptor (Y 1 R) antagonists, such as BIBP 3226 [1] (1; Scheme 1), to be an effective strategy for the [a] Dr.