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3H- and 14C-labelling of the aromatase inhibitor ZK 138723

✍ Scribed by J. Gay; P. Strehlke

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
239 KB
Volume
38
Category
Article
ISSN
0022-2135

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✦ Synopsis

Synthesis of the 3H-and 14C-labelled aromatase inhibitor ZK138723 is described+. The 3H-label was obtained by dehalogenation of a 4,5-diiodoimidazole derivative with tritium gas, yielding 30.8 mCi with a specific activity of 33.4 Cilmmol. Bromine replacement in the thiophene a-position by [14C]cyanide afforded 25.9 mCi of the 14C-labelled material with a specific activity of 55.6 mCi/mmol.

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