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377 IMPLICATION OF CORE GENE IN HBV COVALENTLY CLOSED CIRCULAR DNA ACCUMULATION

✍ Scribed by Fournier, M.; Fresquet, J.; Testoni, B.; Combet, C.; Miailhes, P.; Zoulim, F.

Book ID: 122586546
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 53 KB
Volume: 58
Category: Article
ISSN: 0168-8278
DOI: 10.1016/S0168-8278(13)60379-7

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## Abstract Epigenetic factors may modulate chronic Hepatitis B viral infection by affecting virion gene transcription. The aim of this study was to compare the methylation status of the intrahepatic covalently closed circular DNA (cccDNA) CpG island 2 and HBV replication capability. HBV cccDNA was