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375 Gene expression analysis of galactosamine-induced hepatotoxicity in-vivo and in-vitro

✍ Scribed by H. Hildebrand; G. Kempka; H. Ellinger; B. Stuart; B. Wahle; H.J. Ahr

Book ID
119538144
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
56 KB
Volume
144
Category
Article
ISSN
0378-4274

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## Abstract The study examined the feasibility of screening for hepatotoxicity by an __in vitro__ gene expression analysis using rat primary hepatocytes and Affymetrix Rat Toxicology U34 arrays. Hepatocytes were exposed for 6 or 24 h to eight drugs, with different mechanisms of hepatotoxicity, at o