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361 Anti-tumor Efficacy Profile of a Novel Dual PI3K/mTOR Inhibitor, DS-7423

✍ Scribed by Hirota, Y.; Sato, K.; Hama, Y.; Nagashima, Y.; Watanabe, R.; Suzuki, N.; Sugimura, M.; Shiose, Y.


Book ID
122549019
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
60 KB
Volume
48
Category
Article
ISSN
0959-8049

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The efficacy of a novel, dual PI3K/mTOR
✍ Niranjan Awasthi; Peter L. Yen; Margaret A. Schwarz; Roderich E. Schwarz πŸ“‚ Article πŸ“… 2012 πŸ› John Wiley and Sons 🌐 English βš– 419 KB

## Abstract Gemcitabine has limited clinical benefits for pancreatic ductal adenocarcinoma (PDAC). The phosphatidylinositol‐3‐kinase (PI3K)/AKT and mammalian target of rapamycin (mTOR) signaling pathways are frequently dysregulated in PDAC. We investigated the effects of NVP‐BEZ235, a novel dual PI