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ChemInform Abstract: Identification of GNE-477 (I), a Potent and Efficacious Dual PI3K/mTOR Inhibitor.

✍ Scribed by Timothy P. Heffron; et al. et al.


Publisher
John Wiley and Sons
Year
2010
Weight
18 KB
Volume
41
Category
Article
ISSN
0931-7597

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The efficacy of a novel, dual PI3K/mTOR
✍ Niranjan Awasthi; Peter L. Yen; Margaret A. Schwarz; Roderich E. Schwarz πŸ“‚ Article πŸ“… 2012 πŸ› John Wiley and Sons 🌐 English βš– 419 KB

## Abstract Gemcitabine has limited clinical benefits for pancreatic ductal adenocarcinoma (PDAC). The phosphatidylinositol‐3‐kinase (PI3K)/AKT and mammalian target of rapamycin (mTOR) signaling pathways are frequently dysregulated in PDAC. We investigated the effects of NVP‐BEZ235, a novel dual PI