3,6-dioxoperhydropyrrolo[1,2-a]pyrazines. A new approach to conformationally restricted tripeptides
✍ Scribed by Mercedes Martín-Martínez; Ma Teresa García-López; Rosario González-Muñiz
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 257 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0040-4039
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We describe the synthesis of benzyl (6S)-1, 3-dichloro-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic ester, a new conformationally constrained peptidomimetic derivative. This compound is prepared in seven steps from (S)-pyroglutamic acid as starting material.
## Abstract The 5,6,7,8‐tetrahydro‐1,7‐naphthyridine (**7**) pharmacophore has the potential to serve as a confor‐mationally‐locked analog of the pharmacologically active 2‐(3‐pyridyl)ethylamine (**1**) core structure. This paper describes the synthesis of 5,6,7,8‐tetrahydro‐1,7‐naphthyridine (**7*