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358Early results of a large randomised trial of ‘tomudex’ (raltitrexed) versus 5-fluorouracil (5FU) plus high dose leucovorin (HDLV) in patients with advanced colorectal cancer (ACC)

✍ Scribed by J.J. McAleer; G. Cocconi; G. van Hazel; E. Francois; J.Y. Douillard; K. Possinger; D. Kerr; D. Cunningham; H. Starkhammar; T. Rugg


Book ID
119521607
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
125 KB
Volume
40
Category
Article
ISSN
0167-8140

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Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer