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726 - Long-term weekly treatment of advanced colorectal cancer (CRC) with fluorouracil (5-FU) and leucovorin (LV): 5 year-results of a multicentric phase II trial of 5-FU pharmacokinetic monitoring in 152 patients

✍ Scribed by B. Lamezec; C. Alleaume; E. Gamelin; M.J. Goudier; P.E. Cailleux; E. Danquechin-Dorval; M. Sire; M.L. Maillet; M. Maigre; P. Gesta; P. Maillart; F. Larra

Book ID
117664973
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
217 KB
Volume
33
Category
Article
ISSN
0959-8049

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✍ Enrique Aranda; AndrΓ©s Cervantes; Javier Dorta; Esperanza Blanco; Carlos FernΓ‘nd πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 419 KB πŸ‘ 2 views

Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer