328: Identification and quantification of BRCA1 splicing variants
β Scribed by Lhota, F.; Hojny, J.; Kleiblova, P.; Sevcik, J.; Soukupova, J.; Janatova, M.; Boudova, P.; Borecka, M.; Pohlreich, P.; Kleibl, Z.
- Book ID
- 125797452
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 67 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0959-8049
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Variants of uncertain significance (VUS) in the BRCA1 and BRCA2 genes potentially affecting coding sequence as well as normal splicing activity have confounded predisposition testing in breast cancer. Here, we apply information theory to analyze BRCA1/2 mRNA splicing mutations categorized as VUS. Th
## Abstract The global changes in gene expression induced by transient increased expression of full length BRCA1 as well as the spliced variant BRCA1~S~ were evaluated by cDNA expression array in a human nonβtumorigenic mammary epithelial cell line, MCF10A. Over 30 genes were identified that displa