✦ LIBER ✦

323 POSTER Dependence on PI3K and RAS–RAF pathways drives the activity of the combination of RAD001 and RAF265, a novel inhibitor of the RAF-MAPK pathway

✍ Scribed by P. Mordant; C. Leteur; J. Bourhis; J.C. Soria; E. Deutsch

Book ID: 119599479
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 55 KB
Volume: 6
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(08)72257-2

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Protein and lipid kinase inhibitors as t

Protein and lipid kinase inhibitors as targeted anticancer agents of the Ras/Raf/MEK and PI3K/PKB pathways

✍ Carlos García-Echeverría 📂 Article 📅 2008 🏛 Springer Netherlands 🌐 English ⚖ 197 KB

Constitutive activation of the Raf–MAPK

Constitutive activation of the Raf–MAPK pathway causes negative feedback inhibition of Ras–PI3K–AKT and cellular arrest through the EphA2 receptor

✍ Menges, C W; McCance, D J 📂 Article 📅 2007 🏛 Nature Publishing Group 🌐 English ⚖ 241 KB

Growth factor-dependent activation of th

Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration

✍ Giehl, Klaudia; Skripczynski, Bettina; Mansard, Angela; Menke, Andre; Gierschik, 📂 Article 📅 2000 🏛 Nature Publishing Group 🌐 English ⚖ 325 KB

Effects of the RAF/MEK/ERK and PI3K/AKT

Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells

✍ Shelton, John G; Steelman, Linda S; Lee, John T; Knapp, Steven L; Blalock, Willi 📂 Article 📅 2003 🏛 Nature Publishing Group 🌐 English ⚖ 425 KB

Discovery of 3-(2-aminoethyl)-5-(3-pheny

Discovery of 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione as a dual inhibitor of the Raf/MEK/ERK and the PI3K/Akt signaling pathways

✍ Qianbin Li; Jingde Wu; Hui Zheng; Kai Liu; Tai L. Guo; Yuying Liu; Scott T. Eble 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 710 KB

A thiazolidine-2,4-dione derivative, 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione (2), was identified as a dual inhibitor of the Raf/MEK/ extracellular signal-regulated kinase (ERK) and the phosphatidylinositol 3-kinase (PI3K)/Akt signaling cascades. The discovered compound inhib