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31st Annual Meeting of the Child Neurology Society Abstracts: Poster Session (Behavior)

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
66 KB
Volume
52
Category
Article
ISSN
0364-5134

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Periventricular leukomalacia (PVL) is a major neuropathological substrate in cerebral palsy. PVL is multifactorial. In previous studies, we and others showed that a cytokinemediated immune-inflammatory mechanism involving particularly tumor necrosis factor (TNF)-โฃ is implicated in etiopathogenesis.

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Most cases of cerebral palsy in term infants are unexplained. We studied the association between chorioamnionitis and cerebral palsy in term and near-term infants. We performed a case-control study nested within the cohort of 236,378 singleton infants who weighed more than 2,000gm or who were older