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31P NMR study of cerebral metabolism during prolonged seizures in the neonatal dog

โœ Scribed by Dr. Richard S. K. Young; Mary D. Osbakken; Richard W. Briggs; Susan K. Yagel; David W. Rice; Stuart Goldberg

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
638 KB
Volume
18
Category
Article
ISSN
0364-5134

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โœฆ Synopsis

The effects of prolonged bicuculline-induced seizures on cerebral blood flow and metabolism were determined 1 paralyzed, mechanically ventilated neonatal dogs. Transient changes occurring early in the course of status epileptici included significant arterial hypertension, hypocarbia, elevation of plasma norepinephrine levels, and decline in brai glucose concentration. Cerebral blood flow remained elevated throughout the 45 minutes of seizure. Determination ( cerebral metabolite values by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy and by in vitr enzymatic analysis of frozen brain samples showed significant decreases in the level of phosphocreatine and relative1 less change in ATP values. Progressive intracellular acidosis occurred, coincident with elevation of brain lactat concentrations. We conclude that the physiological and metabolic alterations that occur during prolonged seizures ar not uniform, but change with time. Any hypothesis advanced to explain the mechanism of neuronal injury durin prolonged seizures must take into account these temporally related changes.

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