3.130 Ischemic brain lesion and plasma homocysteine in Parkinson's disease
β Scribed by T. Maeda; K. Nagata; T. Mizuno
- Book ID
- 117753077
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 56 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1353-8020
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## Abstract Homocysteine (Hcy) is a risk factor for vascular diseases, cognitive impairment, and dementia. Elevated plasma concentrations of Hcy have been found recently in Parkinson's disease (PD) patients treated with levodopa, suggesting that levodopa is a cause of hyperhomocysteinemia (HHcy). T
## Abstract Levodopa, typically ingested chronically at high daily doses, is predictably methylated by means of a series of reactions using B vitamins, which convert methionine to homocysteine. Elevated total plasma homocysteine (tHcy), a risk factor for dementia, has been found in PD patients usin