## Abstract We determined the prevalence of two common leucine‐rich repeat kinase 2 (LRRK2) gene mutations in Australian patients with Parkinson's disease (PD). Of 830 affected patients, eight were heterozygous for the G2019S mutation, and two were heterozygous for the R1441H (4,322 G > A) mutation
307: Prevalence of LRRK2 mutations in Australians with Parkinson’s Disease
✍ Scribed by Julia Stevens; Yue Huang; Himesha Vandenbona; Glenda M. Halliday; George Mellick; Frank Mastaglia; John Kwok; Carolyn M. Sue
- Book ID
- 116674212
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 82 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0967-5868
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## Abstract Mutations in the __Leucine‐Rich Repeat Kinase 2__ (__LRRK2__) gene are the most frequent known cause of Parkinson's disease (PD), but their prevalence varies markedly between populations. Here we studied the frequency and associated phenotype of four recurrent __LRRK2__ mutations (R1441
## Abstract Parkinson's disease (PD) is characterized by progressive dopaminergic neuronal loss in the substantia nigra. The recent discovery of __leucine‐rich‐repeat kinase 2__ gene (__LRRK2__) mutations in PD is significant because these mutations are the most common cause of autosomal dominant P