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304 POSTER The predictive and prognostic value of thymidylate synthase and dihydropyrimidine dehydrogenase in primary breast cancer

✍ Scribed by I. Wataru


Book ID
117568898
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
62 KB
Volume
32
Category
Article
ISSN
0748-7983

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## Abstract Cytotoxic effect of 5‐fluorouracil 5‐FU is mediated through inhibition of thymidylate synthase (TS), and 5‐FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5‐FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30