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3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors

โœ Scribed by Ghosh, Arun K.; Thompson, Wayne J.; McKee, Sean P.; Duong, Tien T.; Lyle, Terry A.; Chen, Jenny C.; Darke, Paul L.; Zugay, Joan A.; Emini, Emilio A.


Book ID
126076379
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
332 KB
Volume
36
Category
Article
ISSN
0022-2623

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โœ B. Moon Kim; James P. Guare; Joseph D. Vacca; Stuart R. Michelson; Paul L. Darke ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 297 KB

A series of hydroxyethylpiperazine HIV-1 protease inhibitors containing various monocyclic or bicyclic thienylmethyl substituents as Py ligands were prepared. They were found to exhibit extremely high potency in the enzyme inhibition assay. These inhibitors also proved to be highly effective against