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3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2', 5'-bis-O-(tert-butyldimethylsilyl)-.beta.-D-xylo- and -ribofuranose]-3'-spiro-5''-[4''-amino-1'', 2''-oxathiole 2'', 2''-dioxide] (TSAO) pyrimidine nucleosides

✍ Scribed by Camarasa, Maria Jose; Perez-Perez, Maria Jesus; San-Felix, Ana; Balzarini, Jan; De Clercq, Erik


Book ID
121017223
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
1009 KB
Volume
35
Category
Article
ISSN
0022-2623

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✍ Sonsoles Velázquez; María-Luisa Jimeno; María-José Camarasa; Jan Balzarini 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 716 KB

Reaction of 0-mesylcyanohydrins of fiuanos-2'-ulosyl cytosine with bases afforded B-Darabino-and r&o-2'-spim substituted nucleosides. Two of them exist. in solution, as mixtures of rotatiooally restricted "syn-arm' " isomers.