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Synthesis of [1-[3′,5′-Bis-O-(tert-butyldimethylsilyl)-β-d-arabino- and β-d-ribofuranosyl]cytosine]-2′-spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide). Analogues of the highly specific anti-HIV-1 agent TSAO-T

✍ Scribed by Sonsoles Velázquez; María-Luisa Jimeno; María-José Camarasa; Jan Balzarini

Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 716 KB
Volume: 50
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)85711-2

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✦ Synopsis

Reaction of 0-mesylcyanohydrins of fiuanos-2'-ulosyl cytosine with bases afforded B-Darabino-and r&o-2'-spim substituted nucleosides. Two of them exist. in solution, as mixtures of rotatiooally restricted "syn-arm' " isomers.

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