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3-Nitropropionic acid exacerbates N-methyl-d-aspartate toxicity in striatal culture by multiple mechanisms

โœ Scribed by J.G Greene; S.-S Sheu; R.A Gross; J.T Greenamyre


Book ID
117492124
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
130 KB
Volume
84
Category
Article
ISSN
0306-4522

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The over-activation of glutamate receptors can lead to excitotoxic cell death and is believed to be involved in the progression of neurodegenerative events in the vulnerable hippocampus. Here, we used an in vitro slice model to study toxicity produced in the hippocampus by the mitochondrial toxin 3-