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3-Hydroxyleukotriene B4 (3-OH-LTB4): Total Synthesis and Stereochemical Assignment.

✍ Scribed by Bhatt, Rama K.; Chauhan, Kamlesh; Wheelan, Pat; Falck, J. R.; Murphy, Robert C.

Book ID
121220003
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
936 KB
Volume
116
Category
Article
ISSN
0002-7863

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3(S)-Hydmxy-m B, (la), its 3(R)-epima lb, and a 14.15acetylenic endogue were effWently prepad vie cheletiakamtrolled reduaion of keme 12. obtained by acetylide addition te ehbal Ehydmxylacmes 7p. Leukotriene B4 (LTB,) is an important lipid mediator in inflammatory and immunologic responses.r In rec