3-Hydroxy-3-methylglutaryl-coenzyme A reductase activity is inhibited by cholesterol and up-regulated by sitosterol in sitosterolemic fibroblasts
β Scribed by Akira Honda; Gerald Salen; Megumi Honda; Ashok K Batta; G.Stephen Tint; Guorong Xu; Thomas S Chen; Naomi Tanaka; Sarah Shefer
- Book ID
- 114486277
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 46 KB
- Volume
- 135
- Category
- Article
- ISSN
- 1532-6543
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π SIMILAR VOLUMES
We investigated hepatic cholesterol homeostasis in four homozygous sitosterolemic subjects from two unrelated families who showed enhanced absorption, diminished removal and increased tissue and plasma concentrations of sitosterol (24-ethyl cholesterol). Measurements of hepatic 3-hydroxy-3-methylglu
ative ultracentrifugation as described by Havel et al. 16 using a Sor-Pa Λhlsson Foundation, the Research Foundation of Malmo Β¨University Hospital, the Ernold vall Oil Turbine Drive 75 ultracentrifuge (Sorvall Products, Lundstro Β¨m Foundation, and the Crafoord Foundation. Wilmington, DE). A narrow d